Pharmaceutical product.



UNITED STATES PATENT OFFICE.

MAX ENG-ELMANN AND BENEDIKT OF ELBEBFELD, GERMANY, ASSIGNORS T SYNTHETIC PATENTS 00., ING., OF NEW YORK, N. Y., A CORPORATION OF NEW YORK.

- rmmncnu'ricu. rnonuc'r.

1,126,432. No Drawing.

I To all whom it ma concern:

, Be it known t at we,' fMnx ENGELllIANN and BENEDIKT MERKEL, chemists, citizens of the -German.Empire, residing at Elberfeld, Germany, have invented new and useful Im rovements in Pharmaceutical Prodv nets, 0 tion.

The present invention concerns the production of the hitherto-unknown ethers of alpha-bromoisovalerylisourea having most probably the formula;

which the following is a specifica- (R meaning an allryl, such as CH to be valuable odorless sedatives.v The process for their production consists in treating the ethers of isourea of the forgradually added to .the cooled solution.

The mass of the reaction is then filtered, and the other is distilled. The methyl- Specification of Letters Patent.

Application filed April 8, 1914. Serial N o. 830,886.

more fully the following example is given,

Patented Jan. 26, 1915.

ether of broinoisovalerylisourea having most probably the formula:

remains as an oil, soluble in ether, alcohol,-

benzene and diluted acids and diflicultly soluble in cold water. This ether could not hitherto be obtained in a solid state. Upon treatment with dilute hydrochloric acid it is converted into the bromoisovalerylurea. We claim I v 1. The new products, being chemically ethers of alpha-bromoisovalerylisourea having. most probably the following general formula: I

cH-cH-co-NH-c=n11 cm I,

Br R (R meaning an alkyl, and being oils soluble in alcohol, ether and benzenes; being converted into bromoisovalerylurea upon treatment with dilute hydrochloric acid, substantially as described.

' 2. The new product being chemically the methyleth'en of alpha-bromoisovalerylisourea having most=probably the formula and bein an .oil soluble in ether, alcohol, benzene, lute acids and being soluble with diiiiculty in cold water; being converted into bromoisovalerylurea u on treatment with dilute hydrochloric aci ,substantially as described. In testimony whereof we have hereunto set our hands in the presence of two subscribing witnesses.

.MAX ENGELMANN.) [n s.]

BENEDIKT MERKEL. [1 s.]

Witnesses:

Hum: Norma,- AIBERT Norma; 

